Repair of both normal and reduced AP sites is activated by AP endonuclease, which
recognizes and cleaves a phosphodiester bond 5′ to the AP site. For a short period of time …

Chromatin is no longer considered to be a static structural framework for packaging DNA
within the nucleus but is instead believed to be an interactive component of DNA …

Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle
progression. The participation of chromatin in these events is becoming of increasing …

Fruit and vegetable consumption has consistently been associated with decreased risk of a
number of aerodigestive tract cancers, including esophageal cancer. We have taken a “food …

Previous studies showed that conotruncal heart malformations can arise with the increase or
decrease in α1 connexin function in neural crest cells. To elucidate the possible basis for the …

Histochemistry deals with the activities of chemical components in cells, and
immunohistochemistry addresses the function of cell types in tissue or organs, such as those …

The subcellular distribution and posttranslational modification of human chromatin assembly
factor 1 (CAF-1) have been investigated after UV irradiation of HeLa cells. In an …

To understand the mechanism involved in the coordination of the sequential repair reactions
that lead to long-patch BER, we have investigated interactions between proteins involved in …

The interactions between the tumor suppressor protein p21WAF1 and the cyclin-dependent
kinase (CDK) complexes and with proliferating cell nuclear antigen (PCNA) regulate and …

For several years, our laboratory has been evaluating the ability of lyophilized (freeze-dried)
black raspberries (Rubus occidentalis, BRBs), blackberries (R. fructicosus, BBs), and …