Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease

MA Felmlee, RS Jones, V Rodriguez-Cruz… - Pharmacological …, 2020 - ASPET
The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …

[HTML][HTML] Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis

FD Ni, SL Hao, WX Yang - Cell death & disease, 2019 - nature.com
The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Metabolic regulation is important for spermatogenesis

L Rato, MG Alves, S Socorro, AI Duarte… - Nature Reviews …, 2012 - nature.com
Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …

[HTML][HTML] Molecular mechanisms beyond glucose transport in diabetes-related male infertility

MG Alves, AD Martins, L Rato, PI Moreira… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Diabetes mellitus (DM) is one of the greatest public health threats in modern societies.
Although during a few years it was suggested that DM had no significant effect in male …

Hormonal control of Sertoli cell metabolism regulates spermatogenesis

MG Alves, L Rato, RA Carvalho, PI Moreira… - Cellular and molecular …, 2013 - Springer
Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …

High‐energy diets: a threat for male fertility?

L Rato, MG Alves, JE Cavaco, PF Oliveira - Obesity Reviews, 2014 - Wiley Online Library
Male fertility is declining in developed countries, as well as in developing countries. External
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …

The Warburg effect revisited—lesson from the Sertoli cell

PF Oliveira, AD Martins, AC Moreira… - Medicinal research …, 2015 - Wiley Online Library
Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …

High‐energy diets may induce a pre‐diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters

L Rato, MG Alves, TR Dias, G Lopes, JE Cavaco… - …, 2013 - Wiley Online Library
Diabetes mellitus is a metabolic disorder that may arise from diet habits and is growing to
epidemic proportions. Young male diabetic patients present high infertility/subfertility …

Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function

MG Alves, AD Martins, JE Cavaco, S Socorro… - Tissue …, 2013 - Taylor & Francis
Blood testis barrier (BTB) is one of the tightest blood-barriers controlling the entry of
substances into the intratubular fluid. Diabetes Mellitus (DM) is an epidemic metabolic …

[HTML][HTML] Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

L Rato, AI Duarte, GD Tomas, MS Santos… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at
testicular level. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and …