Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease
MA Felmlee, RS Jones, V Rodriguez-Cruz… - Pharmacological …, 2020 - ASPET
The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …
transporter (MCT) family that play an essential role in the transport of important cell nutrients …
[HTML][HTML] Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis
FD Ni, SL Hao, WX Yang - Cell death & disease, 2019 - nature.com
The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …
Metabolic regulation is important for spermatogenesis
Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …
[HTML][HTML] Molecular mechanisms beyond glucose transport in diabetes-related male infertility
Diabetes mellitus (DM) is one of the greatest public health threats in modern societies.
Although during a few years it was suggested that DM had no significant effect in male …
Although during a few years it was suggested that DM had no significant effect in male …
Hormonal control of Sertoli cell metabolism regulates spermatogenesis
Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …
reach far beyond the physical support of germ cells, as they are responsible for creating the …
High‐energy diets: a threat for male fertility?
Male fertility is declining in developed countries, as well as in developing countries. External
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …
The Warburg effect revisited—lesson from the Sertoli cell
PF Oliveira, AD Martins, AC Moreira… - Medicinal research …, 2015 - Wiley Online Library
Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …
High‐energy diets may induce a pre‐diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters
Diabetes mellitus is a metabolic disorder that may arise from diet habits and is growing to
epidemic proportions. Young male diabetic patients present high infertility/subfertility …
epidemic proportions. Young male diabetic patients present high infertility/subfertility …
Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function
Blood testis barrier (BTB) is one of the tightest blood-barriers controlling the entry of
substances into the intratubular fluid. Diabetes Mellitus (DM) is an epidemic metabolic …
substances into the intratubular fluid. Diabetes Mellitus (DM) is an epidemic metabolic …
[HTML][HTML] Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at
testicular level. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and …
testicular level. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and …