Type 2 diabetes mellitus in older adults: clinical considerations and management

S Bellary, I Kyrou, JE Brown, CJ Bailey - Nature Reviews Endocrinology, 2021 - nature.com
The past 50 years have seen a growing ageing population with an increasing prevalence of
type 2 diabetes mellitus (T2DM); now, nearly half of all individuals with diabetes mellitus are …

From discoveries in ageing research to therapeutics for healthy ageing

J Campisi, P Kapahi, GJ Lithgow, S Melov, JC Newman… - Nature, 2019 - nature.com
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

[HTML][HTML] Examining variation in the measurement of multimorbidity in research: a systematic review of 566 studies

ISS Ho, A Azcoaga-Lorenzo, A Akbari… - The Lancet Public …, 2021 - thelancet.com
Background A systematic understanding of how multimorbidity has been constructed and
measured is unavailable. This review aimed to examine the definition and measurement of …

Multimorbidity and functional impairment–bidirectional interplay, synergistic effects and common pathways

A Calderón‐Larrañaga, DL Vetrano… - Journal of internal …, 2019 - Wiley Online Library
This review discusses the interplay between multimorbidity (ie co‐occurrence of more than
one chronic health condition in an individual) and functional impairment (ie limitations in …

Aging and multimorbidity: new tasks, priorities, and frontiers for integrated gerontological and clinical research

E Fabbri, M Zoli, M Gonzalez-Freire, ME Salive… - Journal of the American …, 2015 - Elsevier
Aging is characterized by rising susceptibility to development of multiple chronic diseases
and, therefore, represents the major risk factor for multimorbidity. From a gerontological …

Multimorbidity care model: Recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life …

K Palmer, A Marengoni, MJ Forjaz, E Jureviciene… - Health Policy, 2018 - Elsevier
Patients with multimorbidity have complex health needs but, due to the current traditional
disease-oriented approach, they face a highly fragmented form of care that leads to …

[HTML][HTML] Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study

H Freisling, V Viallon, H Lennon, V Bagnardi, C Ricci… - BMC medicine, 2020 - Springer
Background Although lifestyle factors have been studied in relation to individual non-
communicable diseases (NCDs), their association with development of a subsequent NCD …

Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity

JL St Sauver, CM Boyd, BR Grossardt, WV Bobo… - BMJ open, 2015 - bmjopen.bmj.com
Objective To study the incidence of de novo multimorbidity across all ages in a
geographically defined population with an emphasis on sex and ethnic differences. Design …

[HTML][HTML] The complex interplay between depression and multimorbidity in late life: risks and pathways

F Triolo, L Harber-Aschan, MB Murri… - Mechanisms of Ageing …, 2020 - Elsevier
Multimorbidity and depression are complex multifactorial conditions with major implications
for older individuals, their families, and healthcare providers. In this scoping review, we …