Highlights•Hepatic stellate cell activation/myofibroblast transition is the main driver of liver
fibrosis.•Paracrine signals from adjacent cells induce stellate cell activation.•Alteration in …

Various factors, including viral and bacterial infections, autoimmune responses, diabetes,
drugs, alcohol abuse, and fat deposition, can damage liver tissue and impair its function …

Biomaterials for tissue scaffolds are key components in modern tissue engineering and
regenerative medicine. Targeted reconstructive therapies require a proper choice of …

Mesenchymal stem cells can be replaced by exosomes for the treatment of inflammatory
diseases, injury repair, degenerative diseases, and tumors. Exosomes are small vesicles …

Stem cell-based therapy appears as a promising strategy to induce regeneration of
damaged and diseased tissues. However, low survival, poor engraftment and a lack of site …

Liver fibrosis is a significant cause of morbidity and mortality without approved treatment.
The therapeutic effects of Imatinib as a tyrosine kinase inhibitor on reversing liver fibrosis …

Background and purpose Umbilical cord-derived mesenchymal stem/stromal cells (UC-
MSCs) are advanced therapy medicinal products (ATMPs) and thus act as an alternative to …

Although multiple drugs are accessible for recovering liver function in patients, none are
considered efficient. Liver transplantation is the mainstay therapy for end-stage liver fibrosis …

Abstract Background Indoleamine 2, 3-dioxygenase 1 (IDO1) has been reported as a
hallmark of hepatic fibrosis. Ginseng Rg1 (G-Rg1) is a characterized bioactive component …

Liver fibrosis is the intermediate process and inevitable stage of the development of chronic
liver disease into cirrhosis. Reducing the degree of liver fibrosis plays an extremely …