[HTML][HTML] miR-381-3p suppresses the proliferation of oral squamous cell carcinoma cells by directly targeting FGFR2

X Yang, H Ruan, X Hu, A Cao… - American journal of cancer …, 2017 - ncbi.nlm.nih.gov
Mutiple microRNAs are implicated in oral squamous cell carcinoma (OSCC), which is
characterized by a high rate of proliferation and nodal metastasis. Data from the present …

Fibroblast growth factor receptor 1 as a target for the therapy of renal cell carcinoma

I Tsimafeyeu, G Bratslavsky - Oncology, 2015 - karger.com
Dysregulation of fibroblast growth factor (FGF) signaling in renal cell carcinoma is now well
understood, and it is becoming increasingly likely that certain tumors become dependent on …

Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

N Kelam, A Racetin, M Polović, B Benzon… - International Journal of …, 2022 - mdpi.com
This study aimed to explore the spatio-temporal expression patterns of congenital anomalies
of kidney and urinary tract (CAKUT) candidate genes, Fibroblast Growth Factor Receptor 1 …

Management of non–clear cell renal cell carcinoma: current approaches

I Tsimafeyeu - Urologic Oncology: Seminars and Original …, 2017 - Elsevier
Non–clear cell renal cell carcinoma includes several histological variants. Tumor biology
has significant effect on the duration of the disease. Prognosis at formally similar disease …

[HTML][HTML] Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models

I Tsimafeyeu, J Ludes-Meyers, E Stepanova… - European Journal of …, 2016 - Elsevier
Alofanib (RPT835) is a novel selective allosteric inhibitor of fibroblast growth factor receptor
2 (FGFR2). We showed previously that alofanib could bind to the extracellular domain of …

Alofanib, an allosteric FGFR2 inhibitor, has potent effects on ovarian cancer growth in preclinical studies

A Tyulyandina, D Harrison, W Yin, E Stepanova… - Investigational new …, 2017 - Springer
Purpose Early data suggest that combining FGFR2 inhibitors with platinum-containing
cytotoxic agents for the treatment of epithelial ovarian cancer may yield increased antitumor …

Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma

HM Surowy, AK Giesen, J Otte, R Büttner… - British Journal of …, 2019 - academic.oup.com
Background Sweat gland carcinomas are rare cutaneous adnexal malignancies. Aggressive
digital papillary adenocarcinoma (ADPA) represents a very rare subentity, thought to arise …

Comprehensive analysis of differentially expressed profiles and reconstruction of a competing endogenous RNA network in papillary renal cell carcinoma

Q Luo, M Cui, Q Deng, J Liu - Molecular medicine …, 2019 - spandidos-publications.com
Long noncoding RNAs (lncRNAs) function as competing endogenous RNAs (ceRNAs).
ceRNA networks may serve important roles in various tumors, as demonstrated by an …

[HTML][HTML] Developing New Peptides and Peptide–Drug Conjugates for Targeting the FGFR2 Receptor-Expressing Tumor Cells and 3D Spheroids

MA Biggs, A Das, BG Goncalves, ME Murray… - Biomimetics, 2024 - mdpi.com
In this work, we utilized a biomimetic approach for targeting KATO (III) tumor cells and 3D
tumoroids. Specifically, the binding interactions of the bioactive short peptide sequences …

[HTML][HTML] Immunochemical expression of fibroblast growth factor and its receptors in primary tumor cells of renal cell carcinoma

M Volkova, I Tsimafeyeu, A Olshanskaya… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Background: There is the evidence of the role of the fibroblast growth factor and its receptors
(FGF/FGFR) signaling pathway in tumorogenesis of renal cell carcinoma (RCC). We …