The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …

Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Different stimulants might induce different extracellular matrix profiles. It is essential to gain
an understanding and quantification of these changes to allow for focused anti-fibrotic drug …

A wound is a type of injury that damages living tissues. In this review, we will be referring
mainly to healing responses in the organs including skin and the lungs. Fibrosis is a process …

Tissue repair is a protective response after injury, but repetitive or prolonged injury can lead
to fibrosis, a pathological state of excessive scarring. To pinpoint the dynamic mechanisms …

Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful
method of identifying high-affinity ligands for a broad range of molecular targets …

Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive
production and accumulation of extracellular matrix, leading to fibrosis of skin and other …