The discovery of RNA interference (RNAi) may well be one of the transforming events in
biology in the past decade. RNAi can result in gene silencing or even in the expulsion of …

Genetically engineered mouse models have significantly contributed to our understanding of
cancer biology. They have proven to be useful in validating gene functions, identifying novel …

The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …

Cardiac failure has a principal underlying aetiology of ischaemic damage arising from
vascular insufficiency. Molecules that regulate collateral growth in the ischaemic heart also …

Tissue-specific transcription factors regulate several important aspects of embryonic
development. They must function in the context of DNA assembled into the higher-order …

Mouse knockout technology provides a powerful means of elucidating gene function in vivo,
and a publicly available genome-wide collection of mouse knockouts would be significantly …

We have generated two lentiviral vectors for conditional, Cre-lox-regulated, RNA
interference. One vector allows for conditional activation, whereas the other permits …

In the past 4 years, RNA interference (RNAi) has become widely used as an experimental
tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an …

RNA interference (RNAi) has been very successfully applied as a gene-silencing technology
in both plants and invertebrates, but many practical obstacles need to be overcome before it …

A cell-based screen of chemical libraries was carried out to identify small molecules that
control the self-renewal of ES cells. A previously uncharacterized heterocycle, SC1, was …