Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …

Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and
recent studies that have sought to reposition ivermectin for the treatment of other diseases …

Ivermectin is one of the most important drugs in veterinary and human medicine for the
control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or …

Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …

Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …

Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic
syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance …

Dirofilaria immitis, also known as heartworm, is a major parasitic threat for dogs and cats
around the world. Because of its impact on the health and welfare of companion animals …

Breast cancer is the most common cancer among women worldwide, yet successful
treatment remains a clinical challenge. Ivermectin, a broad-spectrum antiparasitic drug, has …

The bile acid receptor FXR has emerged as a bona fide drug target for chronic cholestatic
and metabolic liver diseases, ahead of all non-alcoholic fatty liver disease (NAFLD). FXR is …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …