Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

Background Bariatric or weight loss surgery is currently the most effective treatment for
obesity and metabolic disease. Unlike dieting and pharmacology, its beneficial effects are …

Lipoprotein lipase (LPL) hydrolyzes triglycerides from circulating lipoproteins, releasing free
fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for …

Regulation of bile acid metabolism is normally discussed as the regulation of bile acid
synthesis, which serves to compensate for intestinal loss in order to maintain a constant pool …

Bile acids play an active role in fat metabolism and, in high-fat diets, elevated concentrations
of fecal bile acids may be related to an increased risk of colorectal cancer. This study …

Specific bile acids and their signaling pathways play important roles in control of
(cholesterol) metabolism. Deeper insight into the interactions between endogenous (ie, bile …

Health has been defined as the capability of the organism to adapt to challenges. In this
study, we tested to what extent comprehensively phenotyped individuals reveal differences …

Abstract Context Bile acids (BAs) are pivotal signaling molecules that regulate energy
metabolism and inflammation. Recent epidemiological studies have reported specific …