Bile acids and their receptors in metabolic disorders
Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
JYL Chiang, JM Ferrell - American Journal of Physiology …, 2020 - journals.physiology.org
Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …
[HTML][HTML] Animal models to study bile acid metabolism
J Li, PA Dawson - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2019 - Elsevier
The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …
role in studying the relationship between bile acid metabolism and human liver disease …
[HTML][HTML] Regulation of body weight: lessons learned from bariatric surgery
Background Bariatric or weight loss surgery is currently the most effective treatment for
obesity and metabolic disease. Unlike dieting and pharmacology, its beneficial effects are …
obesity and metabolic disease. Unlike dieting and pharmacology, its beneficial effects are …
Structure of dimeric lipoprotein lipase reveals a pore adjacent to the active site
KH Gunn, SB Neher - Nature Communications, 2023 - nature.com
Lipoprotein lipase (LPL) hydrolyzes triglycerides from circulating lipoproteins, releasing free
fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for …
fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for …
Dynamics of the enterohepatic circulation of bile acids in healthy humans
F Stellaard, D Lütjohann - American Journal of Physiology …, 2021 - journals.physiology.org
Regulation of bile acid metabolism is normally discussed as the regulation of bile acid
synthesis, which serves to compensate for intestinal loss in order to maintain a constant pool …
synthesis, which serves to compensate for intestinal loss in order to maintain a constant pool …
Associations between dietary patterns and bile acids—results from a cross-sectional study in vegans and omnivores
I Trefflich, HU Marschall, R Giuseppe, M Ståhlman… - Nutrients, 2019 - mdpi.com
Bile acids play an active role in fat metabolism and, in high-fat diets, elevated concentrations
of fecal bile acids may be related to an increased risk of colorectal cancer. This study …
of fecal bile acids may be related to an increased risk of colorectal cancer. This study …
New insights in the multiple roles of bile acids and their signaling pathways in metabolic control
JF de Boer, VW Bloks, E Verkade… - Current Opinion in …, 2018 - journals.lww.com
Specific bile acids and their signaling pathways play important roles in control of
(cholesterol) metabolism. Deeper insight into the interactions between endogenous (ie, bile …
(cholesterol) metabolism. Deeper insight into the interactions between endogenous (ie, bile …
[HTML][HTML] Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic …
J Fiamoncini, M Rundle, H Gibbons… - FASEB …, 2018 - westminsterresearch.westminster.ac …
Health has been defined as the capability of the organism to adapt to challenges. In this
study, we tested to what extent comprehensively phenotyped individuals reveal differences …
study, we tested to what extent comprehensively phenotyped individuals reveal differences …
Circulating bile acids as biomarkers for disease diagnosis and prevention
L Qi, Y Chen - The Journal of Clinical Endocrinology & …, 2023 - academic.oup.com
Abstract Context Bile acids (BAs) are pivotal signaling molecules that regulate energy
metabolism and inflammation. Recent epidemiological studies have reported specific …
metabolism and inflammation. Recent epidemiological studies have reported specific …