Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Building and maintaining a homeostatic relationship between a host and its colonizing
microbiota entails ongoing complex interactions between the host and the microorganisms …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

Studies in embryonic development have guided successful efforts to direct the differentiation
of human embryonic and induced pluripotent stem cells (PSCs) into specific organ cell types …

Butyrate, one of the SCFA, promotes the development of the intestinal barrier. However, the
molecular mechanisms underlying the butyrate regulation of the intestinal barrier are …

The mucosal surfaces of the gut and airways have important barrier functions and regulate
the induction of immunological tolerance. The rapidly increasing incidence of chronic …

The embryonic program 'epithelial-mesenchymal transition'(EMT) is activated during tumor
invasion in disseminating cancer cells. Characteristic to these cells is a loss of E-cadherin …

The intestinal barrier integrity is essential for the absorption of nutrients and health in
humans and animals. Dysfunction of the mucosal barrier is associated with increased gut …

Background & Aims: In the intestine, the canonical Wnt signaling cascade plays a crucial
role in driving the proliferation of epithelial cells. Furthermore, aberrant activation of Wnt …

Intestinal development in amniotes is driven by interactions between progenitor cells
derived from the three primary germ layers. Genetic analyses and gene targeting …