Leveraging zebrafish to study retinal degenerations

JM Angueyra, KS Kindt - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Retinal degenerations are a heterogeneous group of diseases characterized by death of
photoreceptors and progressive loss of vision. Retinal degenerations are a major cause of …

Turning Müller glia into neural progenitors in the retina

AJ Fischer, R Bongini - Molecular neurobiology, 2010 - Springer
Stimulating neuronal regeneration is a potential strategy to treat sight-threatening diseases
of the retina. In some classes of vertebrates, retinal regeneration occurs spontaneously to …

The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration

BV Fausett, JD Gumerson, D Goldman - Journal of Neuroscience, 2008 - Soc Neuroscience
Unlike mammals, teleost fish can regenerate an injured retina, restoring lost visual function.
Little is known of the molecular events that underlie retina regeneration. We previously …

Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish

Z Qin, LK Barthel, PA Raymond - Proceedings of the …, 2009 - National Acad Sciences
In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-
damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin …

A comparative analysis of Müller glia-mediated regeneration in the vertebrate retina

D Gallina, L Todd, AJ Fischer - Experimental eye research, 2014 - Elsevier
This article reviews the current state of knowledge regarding the potential of Müller glia to
become neuronal progenitor cells in the avian retina. We compare and contrast the …

[HTML][HTML] Investigating regeneration and functional integration of CNS neurons: lessons from zebrafish genetics and other fish species

VC Fleisch, B Fraser, WT Allison - … Acta (BBA)-Molecular Basis of Disease, 2011 - Elsevier
Zebrafish possess a robust, innate CNS regenerative ability. Combined with their genetic
tractability and vertebrate CNS architecture, this ability makes zebrafish an attractive model …

The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short‐living killifish

S Vanhunsel, S Bergmans, A Beckers, I Etienne… - Aging …, 2022 - Wiley Online Library
As the mammalian central nervous system matures, its regenerative ability decreases,
leading to incomplete or non‐recovery from the neurodegenerative diseases and central …

The rod photoreceptor lineage of teleost fish

DL Stenkamp - Progress in retinal and eye research, 2011 - Elsevier
The retinas of postembryonic teleost fish continue to grow for the lifetime of the fish. New
retinal cells are added continuously at the retinal margin, by stem cells residing at the …

Teleost fish as a model system to study successful regeneration of the central nervous system

GKH Zupanc, RF Sîrbulescu - New perspectives in regeneration, 2012 - Springer
Traumatic brain injury and spinal cord injury are devastating conditions that may result in
death or long-term disability. A promising strategy for the development of effective cell …

Purinergic signaling in the retina: From development to disease

ALM Ventura, A dos Santos-Rodrigues, CH Mitchell… - Brain research …, 2019 - Elsevier
Retinal injuries and diseases are major causes of human disability involving vision
impairment by the progressive and permanent loss of retinal neurons. During development …