Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …

A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Cell senescence has been implicated in the pathology of Parkinson's disease (PD). Both
abnormal α-synuclein aggregation and iron deposition are suggested to be the triggers …

Recent studies have shown that impairment of autophagy is related to the pathogenesis of
Parkinson's disease (PD), and small molecular autophagy enhancers are suggested to be …

Background In the last decade, graphene oxide-based nanomaterials, such as graphene
oxide (GO) and reduced graphene oxide (rGO), have attracted more and more attention in …

Neurodegenerative diseases (NDs) are common chronic diseases related to progressive
damage of the nervous system. Globally, the number of people with an ND is dramatically …

Alzheimer's disease (AD) is a growing concern in modern society, and effective drugs for its
treatment are lacking. Uncaria rhynchophylla (UR) and its main alkaloids have been studied …

As an important post-translational modification (PTM), protein phosphorylation is involved in
the regulation of almost all of biological processes in eukaryotes. Due to the rapid progress …

Autophagy is a major clearance pathway for misfolded α-synuclein which promotes
ferroptosis through NCOA4-mediated ferritin degradation. The regulation of these two …