Metastatic and triple-negative breast cancer: challenges and treatment options

S Al-Mahmood, J Sapiezynski, OB Garbuzenko… - Drug delivery and …, 2018 - Springer
The major current conventional types of metastatic breast cancer (MBC) treatments include
surgery, radiation, hormonal therapy, chemotherapy, or immunotherapy. Introducing …

[HTML][HTML] Triple-negative breast cancer: is there a treatment on the horizon?

H Yao, G He, S Yan, C Chen, L Song, TJ Rosol… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC), which accounts for 15–20% of all breast cancers,
does not express estrogen receptor (ER) or progesterone receptor (PR) and lacks human …

[HTML][HTML] The fate of chemoresistance in triple negative breast cancer (TNBC)

EA O'Reilly, L Gubbins, S Sharma, R Tully, MHZ Guang… - BBA clinical, 2015 - Elsevier
Background Treatment options for women presenting with triple negative breast cancer
(TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with …

Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems

CO Silva, JO Pinho, JM Lopes, AJ Almeida, MM Gaspar… - Pharmaceutics, 2019 - mdpi.com
Theranostics has emerged in recent years to provide an efficient and safer alternative in
cancer management. This review presents an updated description of nanotheranostic …

Epidemiology of breast cancer in women

SS Coughlin - Breast Cancer Metastasis and Drug Resistance …, 2019 - Springer
Epidemiologic studies have contributed importantly to current knowledge of environmental
and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of …

Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis

M Pierobon, CL Frankenfeld - Breast cancer research and treatment, 2013 - Springer
Triple-negative breast cancer (TNBC) is a subtype of breast tumor with unique
characteristics in terms of clinical− pathological presentation, prognosis, and response to …

Therapeutic targets of triple‐negative breast cancer: a review

VS Jamdade, N Sethi, NA Mundhe… - British journal of …, 2015 - Wiley Online Library
Breast cancer (BC) is the second most common cause of cancer deaths. Triple‐negative
breast cancer (TNBC) does not show immunohistochemical expression of oestrogen …

The origin of breast tumor heterogeneity

A Skibinski, C Kuperwasser - Oncogene, 2015 - nature.com
How breast diversity is generated is a fascinating and fundamental question with important
clinical implications. It is clear that the diversity of phenotypes displayed by breast cancer …

Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling

S Singh, S Kumar, RK Srivastava, A Nandi… - Nature cell …, 2020 - nature.com
Triple-negative breast cancer (TNBC) is characterized by a high degree of immune infiltrate
in the tumour microenvironment, which may influence the fate of TNBC cells. We reveal that …

Theranostic barcoded nanoparticles for personalized cancer medicine

Z Yaari, D Da Silva, A Zinger, E Goldman… - Nature …, 2016 - nature.com
Personalized medicine promises to revolutionize cancer therapy by matching the most
effective treatment to the individual patient. Using a nanoparticle-based system, we predict …