Key determinants of success in fecal microbiota transplantation: From microbiome to clinic

S Porcari, N Benech, M Valles-Colomer, N Segata… - Cell host & …, 2023 - cell.com
Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …

Machine learning for microbiologists

F Asnicar, AM Thomas, A Passerini… - Nature Reviews …, 2024 - nature.com
Abstract Machine learning is increasingly important in microbiology where it is used for tasks
such as predicting antibiotic resistance and associating human microbiome features with …

Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma

JR Björk, LA Bolte, A Maltez Thomas, KA Lee… - Nature Medicine, 2024 - nature.com
Multiple clinical trials targeting the gut microbiome are being conducted to optimize
treatment outcomes for immune checkpoint blockade (ICB). To improve the success of these …

Inflammatory bowel diseases and gut microbiota

Y Haneishi, Y Furuya, M Hasegawa, A Picarelli… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal tract, the
incidence of which has rapidly increased worldwide, especially in developing and Western …

Utilization of the microbiome in personalized medicine

K Ratiner, D Ciocan, SK Abdeen, E Elinav - Nature Reviews …, 2024 - nature.com
Inter-individual human variability, driven by various genetic and environmental factors,
complicates the ability to develop effective population-based early disease detection …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Role of the microbiota in response to and recovery from cancer therapy

SJ Blake, Y Wolf, B Boursi, DJ Lynn - Nature Reviews Immunology, 2024 - nature.com
Our understanding of how the microbiota affects the balance between response to and
failure of cancer treatment by modulating the tumour microenvironment and systemic …

Assembling symbiotic bacterial species into live therapeutic consortia that reconstitute microbiome functions

RA Oliveira, EG Pamer - Cell Host & Microbe, 2023 - cell.com
Increasing experimental evidence suggests that administering live commensal bacterial
species can optimize microbiome composition and lead to reduced disease severity and …

Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications

PT van Leeuwen, S Brul, J Zhang… - FEMS microbiology …, 2023 - academic.oup.com
The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …

Targeting nonalcoholic fatty liver disease via gut microbiome-centered therapies

M Koning, H Herrema, M Nieuwdorp… - Gut Microbes, 2023 - Taylor & Francis
Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses,
and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit …