Living organisms have evolved various strategies to incorporate sulfur and selenium into
bioactive natural products. These chalcogen-containing compounds serve important and …

Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

Epipolythiodioxopiperazines (ETPs) make up a class of biologically active fungal
metabolites with a transannular disulfide bridge. In this work, we used DFT calculations to …

Two previous unreported epipolythiodioxopiperazines of the emestrin family, namely,
noremestrin A (1) and secoemestrin E (2), were successfully isolated from the fungal source …

Structural studies show that enzymes have a limited number of unique folds, although
structurally related enzymes have evolved to perform a large variety of functions. In this …

The present volume is the third in a trilogy that documents naturally occurring
organohalogen compounds, bringing the total number—from fewer than 25 in 1968—to …

Epidithiodiketopiperazines (ETPs) are a group of bioactive fungal natural products and
structurally feature unique transannular disulfide bridges between α, α or α, β carbons …

Colibactin is a polyketide-nonribosomal peptide hybrid secondary metabolite that can form
interstrand cross-links in double-stranded DNA. Colibactin-producing Escherichia coli has …

Fungal epidithiodiketopiperazines (ETPs) possess large structural diversity and complexity
due to modifications of the cyclodipeptide skeleton. Elucidation of the biosynthetic pathway …

The transannular disulfide functions as a key structural element imparting diverse biological
activities to epidithiodiketopiperazines (ETPs). Although mechanisms were proposed in …