Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

Simple Summary Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an
intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other …

Background The management of advanced clear cell renal cell carcinoma (ccRCC) remains
a major challenge in clinical practice, and the construction of more reliable prognostic …

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …

Bone metastasis is present in a high percentage of breast cancer (BCa) patients with distant
disease, especially in those with the estrogen receptor‐positive (ER+) subtype. Most cells …

Simple Summary A substantial disparity in breast cancer incidence and mortality exists
between African American (AA) and European American (EA) women. However, the basis …

The inflammatory response plays an important role in carcinogenesis. However, the
functional role and mechanism of the UCHL3-associated inflammatory response in ovarian …

Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker
molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 …

Extracellular vesicles (EVs) are emerging as mediators of a range of pathological processes,
including cancer. However, their role in bone metastases has been poorly explored. We …

Tumour necrosis factor receptor-associated factor 6 (TRAF6) has been implicated in breast
cancer and osteoclastic bone destruction. Here, we report that 6877002, a verified small …