Eosinophils are innate immune cells that, under certain conditions, can be recruited to the
lungs, where they have an incompletely understood role in health and disease. Eosinophils …

The quality of care can be improved by the development and implementation of evidence-
based treatment guidelines. Different national guidelines for chronic obstructive pulmonary …

Background The peripheral blood eosinophil count might help identify those patients with
chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations …

Background Randomized controlled trials (RCTs) indicate that long-acting bronchodilator
combinations, such as β2-agonist (LABA)/muscarinic antagonist (LAMA), have favorable …

Background COPD often coexists with chronic conditions that may influence disease
prognosis. We investigated associations between chronic (co) morbidities and …

Inhaled corticosteroids (ICS) are the mainstay of treatment for asthma, but their role in
chronic obstructive pulmonary disease (COPD) is debated. Recent randomised controlled …

Background Tiotropium+ olodaterol has demonstrated improvements beyond lung function
benefits in a large Phase III clinical program as a once-daily maintenance treatment for …

Background Given that physical activity (PA) has a positive impact on COPD symptoms and
prognosis, this study examined the factors that both encourage and limit participation in PA …

Objective Dyspnea is a defining symptom in the classification and treatment of chronic
obstructive pulmonary disease (COPD). However, the degree of variation in burden among …

Background There have been no randomised controlled trials that specifically evaluate the
effect of a comprehensive programme with multidisciplinary input on patients who have just …