Potential therapeutic targets of resveratrol, a plant polyphenol, and its role in the therapy of various types of cancer

SA Almatroodi, M A. Alsahli, A SM Aljohani… - Molecules, 2022 - mdpi.com
Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy
modes employed, including chemotherapy and radiotherapy, have been reported to be …

Broad-spectrum preclinical antitumor activity of chrysin: current trends and future perspectives

ER Moghadam, HL Ang, SE Asnaf, A Zabolian… - Biomolecules, 2020 - mdpi.com
Pharmacological profile of phytochemicals has attracted much attention to their use in
disease therapy. Since cancer is a major problem for public health with high mortality and …

Biodegradable and dissolvable resveratrol nanocrystals non-silicon microneedles for transdermal drug delivery

Y Liu, Z Zhang, C Wang, X Xie, Y Ma, Y Wang - Journal of Drug Delivery …, 2023 - Elsevier
The prevalence and lethality of cutaneous melanoma have increased in recent years. Lower
skin penetration rates and poor soluble affect the effective delivery of resveratrol. To …

Multiple effects of resveratrol on osteosarcoma cell lines

A De Luca, D Bellavia, L Raimondi, V Carina, V Costa… - Pharmaceuticals, 2022 - mdpi.com
Osteosarcoma (OS) is the most common primary bone sarcoma affecting the life of pediatric
patients. The clinical treatment faces numerous difficulties, including the adverse effects of …

Shedding light on the interaction of polydatin and resveratrol with G-quadruplex and duplex DNA: A biophysical, computational and biological approach

C Platella, U Raucci, N Rega, S D'Atri, L Levati… - International journal of …, 2020 - Elsevier
Among polyphenols, trans-resveratrol (tRES) and trans-polydatin (tPD) exert multiple
biological effects, particularly antioxidant and antiproliferative. In this work, we have …

Melanoma Cellular Signaling Transduction Pathways Targeted by Polyphenols Action Mechanisms

E Isacescu, P Chiroi, O Zanoaga, A Nutu, L Budisan… - Antioxidants, 2023 - mdpi.com
Melanoma is the most aggressive type of skin cancer. Although different anti-melanoma
treatments are available, their efficacy is still improvable, and the number of deaths …

Cynaroside Induces G1 Cell Cycle Arrest by Downregulating Cell Division Cycle 25A in Colorectal Cancer

S Lei, W Cao, Z Zeng, L Wang, J Lan, T Chen - Molecules, 2024 - mdpi.com
Natural chemicals derived from herbal plants have recently been recognized as potentially
useful treatment alternatives owing to their ability to target a wide range of important …

Pterostilbene-mediated inhibition of cell proliferation and cell death induction in amelanotic and melanotic melanoma

J Wawszczyk, K Jesse, M Kapral - International Journal of Molecular …, 2023 - mdpi.com
Melanoma is one of the fastest-growing cancers worldwide. Treatment of advanced
melanoma is very difficult; therefore, there is growing interest in the identification of new …

Porcupine quills keratin peptides induces G0/G1 cell cycle arrest and apoptosis via p53/p21 pathway and caspase cascade reaction in MCF‐7 breast cancer cells

K Wang, Y Xu, H Huang, D Peng… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Porcupine quills, a by‐product of porcupine pork, are rich in keratin, which
is an excellent source of bioactive peptides. The objective of this study was to investigate the …

Screening of anti-melanoma compounds from Morus alba L.: Sanggenon C promotes melanoma cell apoptosis by disrupting intracellular Ca2+ homeostasis

X Hu, J Li, L Yu, J Ifejola, Y Guo, D Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Morus alba L. is a widespread plant that has long been
considered to have remarkable medical values, including anti-inflammation in Traditional …