Parkinson's disease: from pathogenesis to pharmacogenomics

R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …

Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics

A Kulkarni, K Preeti, KP Tryphena, S Srivastava… - Ageing Research …, 2023 - Elsevier
The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

Epigenetic mechanisms in neurological and neurodegenerative diseases

J Landgrave-Gómez, O Mercado-Gómez… - Frontiers in cellular …, 2015 - frontiersin.org
The role of epigenetic mechanisms in the function and homeostasis of the central nervous
system (CNS) and its regulation in diseases is one of the most interesting processes of …

Epigenetic and neurological impairments associated with early life exposure to persistent organic pollutants

N Grova, H Schroeder, JL Olivier… - International journal of …, 2019 - Wiley Online Library
The incidence of neurodevelopmental and neurodegenerative diseases worldwide has
dramatically increased over the last decades. Although the aetiology remains uncertain …

Epigenetic mechanisms in Parkinson's disease

Y Feng, J Jankovic, YC Wu - Journal of the neurological sciences, 2015 - Elsevier
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD …

Targeting epigenetic modifications in Parkinson's disease therapy

D Zhang, J Zhang, Y Wang, G Wang… - Medicinal Research …, 2023 - Wiley Online Library
Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

[HTML][HTML] Pathological histone acetylation in Parkinson's disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition

IF Harrison, AD Smith, DT Dexter - Neuroscience letters, 2018 - Elsevier
Parkinson's disease (PD) is associated with degeneration of nigrostriatal neurons due to
intracytoplasmic inclusions composed predominantly of a synaptic protein called α …

Implications of DNA methylation in Parkinson's disease

E Miranda-Morales, K Meier… - Frontiers in molecular …, 2017 - frontiersin.org
It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects
of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative …