RyR2 and calcium release in heart failure
JP Benitah, R Perrier, JJ Mercadier, L Pereira… - Frontiers in …, 2021 - frontiersin.org
Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
2019 ESC guidelines for the management of patients with supraventricular tachycardia the task force for the management of patients with supraventricular tachycardia …
J Brugada, DG Katritsis, E Arbelo, F Arribas… - European heart …, 2020 - academic.oup.com
Supraventricular arrhythmias are common and patients are often symptomatic, requiring
management with drugs and electrophysiological procedures. The ESC published …
management with drugs and electrophysiological procedures. The ESC published …
Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction
Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …
Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative …
Aims Loss-of-function mutations in Calsequestrin 2 (CASQ2) are associated with
catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit …
catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit …
Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways
Introduction Despite a century of extensive study on the human sinoatrial node (SAN), the
structure-to-function features of specialized SAN conduction pathways (SACP) are still …
structure-to-function features of specialized SAN conduction pathways (SACP) are still …
Modeling atrial fibrillation using human embryonic stem cell-derived atrial tissue
Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we
used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF …
used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF …
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and
whether human SAN excitability requires voltage-gated sodium channels (Nav) remains …
whether human SAN excitability requires voltage-gated sodium channels (Nav) remains …
Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node function
The mechanisms responsible for exercise-induced reductions in baseline heart rate (HR),
known as training bradycardia, remain controversial. Therefore, changes in cardiac …
known as training bradycardia, remain controversial. Therefore, changes in cardiac …
Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed …
Background—Although sinoatrial node (SAN) dysfunction is a hallmark of human heart
failure (HF), the underlying mechanisms remain poorly understood. We aimed to examine …
failure (HF), the underlying mechanisms remain poorly understood. We aimed to examine …
Hippo-yap signaling maintains sinoatrial node homeostasis
Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating
rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood …
rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood …