Therapeutic options for patients with amyotrophic lateral sclerosis (ALS) are currently
limited. However, recent studies show that almost all cases of ALS, as well as tau-negative …

During neurodegenerative disease, the multifunctional RNA-binding protein TDP-43
undergoes a vast array of post-translational modifications, including phosphorylation …

The discovery that prion protein can misfold into a pathological conformation that encodes
structural information capable of both propagation and inducing severe neuropathology has …

Introduction: Nuclear factor TDP-43 is a ubiquitously expressed RNA binding protein that
plays a key causative role in several neurodegenerative diseases, especially in the …

TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural
resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent a
continuum of devastating neurodegenerative diseases, characterized by transactive …

Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease
associated with protein misfolding and aggregation. Most cases are characterized by TDP …

TDP-43 is a nuclear factor that functions in promoting pre-mRNA splicing. Deletion of the N-
terminal domain (NTD) and nuclear localization signal (NLS)(ie, TDP-35) results in …

TDP-43 (TAR DNA-binding protein of 43 kDa) is a major deposited protein in amyotrophic
lateral sclerosis and frontotemporal dementia with ubiquitin. A great number of genetic …

ABSTRACT TDP-43 (also known as TARDBP) is a pathological signature protein of
neurodegenerative diseases, with TDP-43 proteinopathies including frontotemporal lobar …