Applications of focused ultrasound in the brain: from thermoablation to drug delivery
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …
clinic represents the culmination of decades of research. Lying at the convergence of …
Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases
J Wang, Z Li, M Pan, M Fiaz, Y Hao, Y Yan… - Advanced Drug Delivery …, 2022 - Elsevier
Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …
Ultrasound as a versatile tool for short-and long-term improvement and monitoring of brain function
DG Blackmore, D Razansky, J Götz - Neuron, 2023 - cell.com
Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates
An emerging approach with potential in improving the treatment of neurodegenerative
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …
PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma?
M Khasraw, DA Reardon, M Weller, JH Sampson - Clinical Cancer Research, 2020 - AACR
Glioblastoma (WHO grade IV glioma) is the most common malignant primary brain tumor in
adults. Survival has remained largely static for decades, despite significant efforts to develop …
adults. Survival has remained largely static for decades, despite significant efforts to develop …
[HTML][HTML] Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients
ME Karakatsani, R Ji, MF Murillo, T Kugelman… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Bilateral sonication with focused ultrasound (FUS) in conjunction with
microbubbles has been shown to separately reduce amyloid plaques and …
microbubbles has been shown to separately reduce amyloid plaques and …
Cavitation-modulated inflammatory response following focused ultrasound blood-brain barrier opening
Focused ultrasound (FUS) in combination with systemically injected microbubbles can be
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …
Focused ultrasound mediated blood–brain barrier opening is safe and feasible in a murine pontine glioma model
Drug delivery in diffuse intrinsic pontine glioma is significantly limited by the blood-brain
barrier (BBB). Focused ultrasound (FUS), when combined with the administration of …
barrier (BBB). Focused ultrasound (FUS), when combined with the administration of …
Focused ultrasound-mediated blood-brain barrier opening increases delivery and efficacy of etoposide for glioblastoma treatment
Purpose Glioblastoma (GBM) is a devastating disease. With the current treatment of surgery
followed by chemoradiation, outcomes remain poor, with median survival of only 15 months …
followed by chemoradiation, outcomes remain poor, with median survival of only 15 months …
Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound
Low-intensity ultrasound combined with intravenously injected microbubbles (US+ MB) is a
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …