TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue
damage not only induces inflammation in general, it also determines the type and …

Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

The dose-dependent toxicity to cardiomyocytes has been well recognized as a central
characteristic of doxorubicin (DOX)-induced cardiotoxicity (DIC), however, the pathogenesis …

Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

Endothelial cells that line the inner walls of blood vessels are in direct contact with blood
and display remarkable heterogeneity in their response to exogenous stimuli. These ECs …

Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive
transcriptional reprogramming of activated endothelial cells leading to a shift toward …

As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …