Metastasis is directly or indirectly responsible for the majority of cancer deaths. Anti-
metastasis treatment is thus the key to cure cancer. Recent development in nanomedicine …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …

Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely
different effects in various target organs. Here we show that tumour-secreted DKK1 is a …

Monoclonal antibodies can block cellular interactions that negatively regulate T-cell immune
responses, such as CD80/CTLA-4 and PD-1/PD1-L, amplifying preexisting immunity and …

Pulmonary metastasis of breast cancer requires recruitment and expansion of T-regulatory
cells (Treg) that promote escape from host protective immune cells. However, it remains …

The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic
and invasive and, unlike most tumor models, can spontaneously metastasize from the …

Despite evidence supporting an oncogenic role in breast cancer, the Notch pathway's
contribution to metastasis remains unknown. Here, we report that the Notch ligand Jagged1 …

Purpose: Ionizing radiation therapy (RT) is an important component in the management of
breast cancer. Although the primary tumor can be successfully treated by surgery and RT …

The translation of basic research into improved therapies for breast cancer patients requires
relevant preclinical models that incorporate spontaneous metastasis. We have completed a …