Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …

Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations
have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their …

Ischemia‐reperfusion (I/R) is a pathological process that occurs in many organs and
diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion …

Introduction Inflammation is a defensive response of the organism to irritation which is
manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response …

Cardiac dysfunction is a common complication of sepsis, and is attributed to severe
inflammatory responses. Ferroptosis is reported to be involved in sepsis-induced cardiac …

Background Steatotic livers tolerate ischemia–reperfusion injury (IRI) poorly, increasing the
risk of organ dysfunction. Ferroptosis is considered the initiating factor of organ IRI. Heme …