RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

Ribonucleases (RNases) are a type of nucleases that catalyze the degradation of RNA into
smaller components. They exist in a wide range of life forms from prokaryotes to eukaryotes …

A very fast empirical method is presented for structure‐based protein pKa prediction and
rationalization. The desolvation effects and intra‐protein interactions, which cause variations …

Immunotoxins (ITXs) are chimeric molecules that combine the specificity of a targeting
domain, usually derived from an antibody, and the cytotoxic potency of a toxin, leading to the …

α‐Sarcin is a ribosome‐inactivating protein that has been well characterized in vitro, but little
is known about its toxicity in living cells. We have analyzed the mechanism of internalization …

Fungi establish a complex network of biological interactions with other organisms in nature.
In many cases, these involve the production of toxins for survival or colonization purposes …

Skin testing is a basic diagnostic procedure widely used to explore immediate-type reactions
to allergen preparations in vivo. Despite their reliability, if standardized extracts are used …

Animal models of aspergillosis have been used extensively to study various aspects of
pathogenesis, innate and acquired host-response, disease transmission and therapy …

Experiments in cell-free systems have demonstrated that the VP5* cleavage fragment of the
rotavirus spike protein, VP4, undergoes a foldback rearrangement that translocates three …

Explicit solvent molecular dynamics (MD) simulations were carried out for sarcin–ricin
domain (SRD) motifs from 23S (Escherichia coli) and 28S (rat) rRNAs. The SRD motif …