The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …

Non-small cell lung cancer (NSCLC) has the highest mortality rate among all malignancies
worldwide. The role of long noncoding RNAs (lncRNAs) in the progression of cancers is a …