[HTML][HTML] Unraveling hematopoiesis through the lens of genomics
LA Liggett, VG Sankaran - Cell, 2020 - cell.com
Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis.
In the past decade, the genomics revolution has ushered in powerful new methods for …
In the past decade, the genomics revolution has ushered in powerful new methods for …
Epidemiology, genetics and treatment of multiple myeloma and precursor diseases
K Hemminki, A Försti, R Houlston… - International journal of …, 2021 - Wiley Online Library
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of
plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 …
plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 …
Deciphering the genetics and mechanisms of predisposition to multiple myeloma
M Went, L Duran-Lozano, GH Halldorsson… - Nature …, 2024 - nature.com
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies
indicate a substantial heritable component, but the underlying mechanisms remain unclear …
indicate a substantial heritable component, but the underlying mechanisms remain unclear …
Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk
Estimating familial cancer risks is clinically important in being able to discriminate between
individuals in the population at differing risk for malignancy. To gain insight into the familial …
individuals in the population at differing risk for malignancy. To gain insight into the familial …
[HTML][HTML] Artificial intelligence predicted overall survival and classified mature B-cell neoplasms based on immuno-oncology and immune checkpoint panels
Simple Summary Artificial intelligence (AI) is a field that combines computer science with
robust datasets to solve problems. AI in medicine uses machine learning and deep learning …
robust datasets to solve problems. AI in medicine uses machine learning and deep learning …
Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
ABSTRACT DNA molecules are highly compacted in the eukaryotic nucleus where distal
regulatory elements reach their targets through three-dimensional chromosomal …
regulatory elements reach their targets through three-dimensional chromosomal …
Genome instability in multiple myeloma: Facts and factors
Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
The impact of tumor heterogeneity on diagnostics and novel therapeutic strategies in multiple myeloma
Myeloma is characterized by extensive inter-patient genomic heterogeneity due to multiple
different initiating events. A recent multi-region sequencing study demonstrated spatial …
different initiating events. A recent multi-region sequencing study demonstrated spatial …
Next-generation sequencing for clinical management of multiple myeloma: ready for prime time?
Personalized treatment is an attractive strategy that promises increased efficacy with
reduced side effects in cancer. The feasibility of such an approach has been greatly boosted …
reduced side effects in cancer. The feasibility of such an approach has been greatly boosted …
Proteasome inhibition in combination with immunotherapies: State-of-the-Art in multiple myeloma
Multiple myeloma (MM) is a malignant plasma cell disorder accounting for around 1.8% of
all neoplastic diseases. Nowadays, clinicians have a broad arsenal of drugs at their disposal …
all neoplastic diseases. Nowadays, clinicians have a broad arsenal of drugs at their disposal …