The unique structural and functional features of CXCL12

R Janssens, S Struyf, P Proost - Cellular & molecular immunology, 2018 - nature.com
The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

Chemokines from a structural perspective

MC Miller, KH Mayo - International journal of molecular sciences, 2017 - mdpi.com
Chemokines are a family of small, highly conserved cytokines that mediate various
biological processes, including chemotaxis, hematopoiesis, and angiogenesis, and that …

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

B Wu, EYT Chien, CD Mol, G Fenalti, W Liu, V Katritch… - Science, 2010 - science.org
Chemokine receptors are critical regulators of cell migration in the context of immune
surveillance, inflammation, and development. The G protein–coupled chemokine receptor …

Mechanisms of regulation of the chemokine-receptor network

MJ Stone, JA Hayward, C Huang, Z E. Huma… - International journal of …, 2017 - mdpi.com
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

The role of the CXCL12/CXCR4/ACKR3 axis in autoimmune diseases

EM García-Cuesta, CA Santiago… - Frontiers in …, 2019 - frontiersin.org
Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor

JS Burg, JR Ingram, AJ Venkatakrishnan, KM Jude… - Science, 2015 - science.org
Chemokines are small proteins that function as immune modulators through activation of
chemokine G protein–coupled receptors (GPCRs). Several viruses also encode chemokines …

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

L Qin, I Kufareva, LG Holden, C Wang, Y Zheng… - Science, 2015 - science.org
Chemokines and their receptors control cell migration during development, immune system
responses, and in numerous diseases, including inflammation and cancer. The structural …

CXCR7/CXCR4 heterodimer constitutively recruits β-arrestin to enhance cell migration

FM Décaillot, MA Kazmi, Y Lin, S Ray-Saha… - Journal of Biological …, 2011 - ASBMB
G protein-coupled receptor hetero-oligomerization is emerging as an important regulator of
ligand-dependent transmembrane signaling, but precisely how receptor heteromers affect …

Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives

L Pawig, C Klasen, C Weber, J Bernhagen… - Frontiers in …, 2015 - frontiersin.org
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

Unleashing the potential of noncanonical amino acid biosynthesis to create cells with precision tyrosine sulfation

Y Chen, S Jin, M Zhang, Y Hu, KL Wu, A Chung… - Nature …, 2022 - nature.com
Despite the great promise of genetic code expansion technology to modulate structures and
functions of proteins, external addition of ncAAs is required in most cases and it often limits …