BACKGROUND The epididymis performs an important role in the maturation of spermatozoa
including their acquisition of progressive motility and fertilizing ability. However, the …

OBJECTIVE: To illustrate the necessity for an enhanced understanding of the genetic basis
of male factor infertility, to present a comprehensive synopsis of these genetic elements, and …

The use of antioxidants in treatment of infertile men has been suggested, although the
evidence base for this practice is unclear. A systematic review of randomized studies was …

Azoospermia due to obstructive and non-obstructive mechanisms is a common
manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors …

The fundamental underlying paradigm of sexual reproduction is the production of male and
female gametes of sufficient genetic difference and quality that, following syngamy, they …

Background The assisted reproductive techniques aimed to assist infertile couples have
their own offspring carry significant risks of passing on molecular defects to next …

BACKGROUND DNA damage is a hazard that affects all cells of the body. DNA-damage
repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are …

Microdissection testicular sperm extraction (microTESE) is considered the gold standard
method for surgical sperm retrieval among patients with non-obstructive azoospermia …

Highlights•During ART treatment, gametes and embryos are exposed to non-physiological
processes.•The short-and long-term safety of assisted reproduction is of concern.•There is …

OBJECTIVE: To review established genetic causes of azoospermia, the most severe form of
male infertility, and help clinicians, scientists, and infertile couples considering assisted …