Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …

Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory
neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …