Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Spheroid culture system methods and applications for mesenchymal stem cells
Owing to the importance of stem cell culture systems in clinical applications, researchers
have extensively studied them to optimize the culture conditions and increase efficiency of …
have extensively studied them to optimize the culture conditions and increase efficiency of …
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses
LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …
shown the therapeutic potential effect of MSC or their derived products. However, the …
Effect of the microenvironment on mesenchymal stem cell paracrine signaling: opportunities to engineer the therapeutic effect
Cues from the extracellular environment, including physical stimuli, are well known to affect
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …
Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration
Y Cao, J Tan, H Zhao, T Deng, Y Hu, J Zeng… - Nature …, 2022 - nature.com
Transplantation of mesenchymal stem cells (MSCs) holds promise to repair severe traumatic
injuries. However, current transplantation practices limit the potential of this technique, either …
injuries. However, current transplantation practices limit the potential of this technique, either …
Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs
N Di Caprio, JA Burdick - Acta biomaterialia, 2023 - Elsevier
Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …
biological questions and as building blocks for engineered tissues. Spheroids possess …
Macroscale biomaterials strategies for local immunomodulation
The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …
manipulation of innate and adaptive immune responses is of great promise for a wide array …
Direct 3D printed biomimetic scaffolds based on hydrogel microparticles for cell spheroid growth
Biocompatible hydrogel inks with shear‐thinning, appropriate yield strength, and fast self‐
healing are desired for 3D bioprinting. However, the lack of ideal 3D bioprinting inks with …
healing are desired for 3D bioprinting. However, the lack of ideal 3D bioprinting inks with …
Biomaterials for cell transplantation
N Mitrousis, A Fokina, MS Shoichet - Nature Reviews Materials, 2018 - nature.com
Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …
Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs
Mesenchymal stromal cells (MSCs) secrete paracrine factors that play crucial roles during
tissue regeneration. Whether this paracrine function is influenced by the properties of …
tissue regeneration. Whether this paracrine function is influenced by the properties of …