Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Spheroid culture system methods and applications for mesenchymal stem cells

NE Ryu, SH Lee, H Park - Cells, 2019 - mdpi.com
Owing to the importance of stem cell culture systems in clinical applications, researchers
have extensively studied them to optimize the culture conditions and increase efficiency of …

Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

Effect of the microenvironment on mesenchymal stem cell paracrine signaling: opportunities to engineer the therapeutic effect

GD Kusuma, J Carthew, R Lim… - Stem cells and …, 2017 - liebertpub.com
Cues from the extracellular environment, including physical stimuli, are well known to affect
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …

Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration

Y Cao, J Tan, H Zhao, T Deng, Y Hu, J Zeng… - Nature …, 2022 - nature.com
Transplantation of mesenchymal stem cells (MSCs) holds promise to repair severe traumatic
injuries. However, current transplantation practices limit the potential of this technique, either …

Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs

N Di Caprio, JA Burdick - Acta biomaterialia, 2023 - Elsevier
Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …

Macroscale biomaterials strategies for local immunomodulation

MO Dellacherie, BR Seo, DJ Mooney - Nature Reviews Materials, 2019 - nature.com
The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …

Direct 3D printed biomimetic scaffolds based on hydrogel microparticles for cell spheroid growth

H Zhang, Y Cong, AR Osi, Y Zhou… - Advanced Functional …, 2020 - Wiley Online Library
Biocompatible hydrogel inks with shear‐thinning, appropriate yield strength, and fast self‐
healing are desired for 3D bioprinting. However, the lack of ideal 3D bioprinting inks with …

Biomaterials for cell transplantation

N Mitrousis, A Fokina, MS Shoichet - Nature Reviews Materials, 2018 - nature.com
Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …

Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs

TH Qazi, DJ Mooney, GN Duda, S Geissler - Biomaterials, 2017 - Elsevier
Mesenchymal stromal cells (MSCs) secrete paracrine factors that play crucial roles during
tissue regeneration. Whether this paracrine function is influenced by the properties of …