Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Troponin is a molecular switch, directly regulating the Ca 2+-dependent activation of
myofilament in striated muscle contraction. Cardiac troponin is subject to covalent and …

Troponin is essential in Ca2+ regulation of skeletal and cardiac muscle contraction. It
consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on …

The number of structures of protein–protein complexes deposited to the Protein Data Bank is
growing rapidly. These structures embed important information for predicting structures of …

Cardiac failure is one of the leading causes of mortality in developed countries. As life
expectancies of the populations of these countries grow, the number of patients suffering …

Muscle ultrastructure is characterised by a complex arrangement of many protein-protein
interactions. The sarcomere is the basic repeating unit of muscle, formed by two transverse …

Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …

Synthesizes the current knowledge in the field and provides new insights into medical
applications Metalloproteomics is the large-scale study of metal-binding proteins. These …

Heart disease, the leading cause of death worldwide, refers to various illnesses that affect
heart structure and function. Specific abnormalities affecting cardiac muscle contractility and …

Cardiac troponin C (cTnC) is the calcium-dependent switch for contraction in heart muscle
and a potential target for drugs in the therapy of congestive heart failure. This calmodulin …