Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent
and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and …

The central nervous system has long been thought to regulate insulin secretion, an essential
process in the maintenance of blood glucose levels. However, the anatomical and functional …

Type 2 diabetes (T2D) is characterized by insulin resistance along with pancreatic β cell
failure. β cell factors are traditionally thought to control glucose homeostasis by modulating …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

Background The diagnosis of hypoglycemia and the use of diazoxide have risen in the last
decade. Diazoxide is the only Food and Drug Agency-approved pharmacologic treatment for …

Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin
release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe …

Abstract Knowledge of ectopic insulinomas comes from single cases. We performed a
systematic review through PubMed, Web of Science, Embase, eLibrary and ScienceDirect of …

Hypoglycemia is defined by a low blood glucose level associated to clinical symptoms.
Hypoglycemia may be related to treatment of diabetes, but also to drugs, alcohol, critical …