Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Results obtained from completed and on-going clinical studies indicate huge therapeutic
potential of stem cell-based therapy in the treatment of degenerative, autoimmune and …

During embryonic development, epithelial cell blocks called somites are periodically formed
according to the segmentation clock, becoming the foundation for the segmental pattern of …

Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Differential speeds in biochemical reactions have been proposed to be responsible for the
differences in developmental tempo between mice and humans. However, the underlying …

It is extremely rare for a single experiment to be so impactful and timely that it shapes and
forecasts the experiments of the next decade. Here, we review how two such experiments …