The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …

The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also
known as VR1) antagonists is based on the concept that endogenous agonists acting on …

Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable
nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 …

Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel
treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and …

PGC1α is a key transcriptional coregulator of oxidative metabolism and thermogenesis.
Through a high-throughput chemical screen, we found that molecules antagonizing the …

Peripheral neuropathy is dose limiting in paclitaxel cancer chemotherapy and can result in
both acute pain during treatment and chronic persistent pain in cancer survivors. The …

Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of
pain associated with inflammatory diseases and cancer. Hence, TRPV1 antagonists have …

Living organisms must evaluate changes in environmental and internal temperatures to
mount appropriate physiological and behavioral responses conducive to survival. Classical …