[HTML][HTML] The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review
L Li, C Chen, C Chiang, T Xiao, Y Chen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …
transmembrane protein that can be activated by various physical and chemical stimuli and is …
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
A Szallasi, DN Cortright, CA Blum, SR Eid - Nature reviews Drug …, 2007 - nature.com
The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
TRPM3 is a nociceptor channel involved in the detection of noxious heat
J Vriens, G Owsianik, T Hofmann, SE Philipp, J Stab… - Neuron, 2011 - cell.com
Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable
nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 …
nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 …
Electroacupuncture alleviates paclitaxel-induced peripheral neuropathic pain in rats via suppressing TLR4 signaling and TRPV1 upregulation in sensory neurons
Y Li, C Yin, X Li, B Liu, J Wang, X Zheng… - International journal of …, 2019 - mdpi.com
Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel
treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and …
treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and …
[HTML][HTML] TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
PGC1α is a key transcriptional coregulator of oxidative metabolism and thermogenesis.
Through a high-throughput chemical screen, we found that molecules antagonizing the …
Through a high-throughput chemical screen, we found that molecules antagonizing the …
The cancer chemotherapeutic paclitaxel increases human and rodent sensory neuron responses to TRPV1 by activation of TLR4
Peripheral neuropathy is dose limiting in paclitaxel cancer chemotherapy and can result in
both acute pain during treatment and chronic persistent pain in cancer survivors. The …
both acute pain during treatment and chronic persistent pain in cancer survivors. The …
Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions
YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
TRP channels in skin biology and pathophysiology
MJ Caterina, Z Pang - Pharmaceuticals, 2016 - mdpi.com
Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …
monovalent and/or divalent cations into cells in response to a host of chemical or physical …
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of
pain associated with inflammatory diseases and cancer. Hence, TRPV1 antagonists have …
pain associated with inflammatory diseases and cancer. Hence, TRPV1 antagonists have …
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
MJ Caterina - American Journal of Physiology-Regulatory …, 2007 - journals.physiology.org
Living organisms must evaluate changes in environmental and internal temperatures to
mount appropriate physiological and behavioral responses conducive to survival. Classical …
mount appropriate physiological and behavioral responses conducive to survival. Classical …