The mechanistic influences of dopamine (DA) signaling and impact on motor function are
nearly always interpreted from changes in nigrostriatal neuron terminals in striatum. This is a …

Compensatory mechanisms that augment dopamine (DA) signaling are thought to mitigate
onset of hypokinesia prior to major loss of tyrosine hydroxylase (TH) in striatum that occurs …

Although glial cell line-derived neurotrophic factor (GDNF) showed efficacy in preclinical
and early clinical studies to alleviate parkinsonian signs in Parkinson's disease (PD), later …

Parkinson's disease (PD) rodent models provide insight into the relationship between
nigrostriatal dopamine (DA) signaling and locomotor function. Although toxin-based rat …

Understanding the intricate role of dopamine D1–D5 receptors is pivotal in addressing the
challenges posed by the aging global population, as well as by social stress and advancing …

DPAGT1-CDG is a Congenital Disorder of Glycosylation (CDG) that lacks effective therapies.
It is caused by mutations in the gene DPAGT1 which encodes the first enzyme in N-linked …

Alleviation of motor impairment by aerobic exercise (AE) in Parkinson's disease (PD)
patients points to activation of neurobiological mechanisms that may be targetable by …

Stress is associated with contextual memory deficits, which may mediate avoidance of
trauma‐associated contexts in posttraumatic stress disorder. These deficits may emerge …

Mechanisms that augment dopamine (DA) signaling to compensate for tyrosine hydroxylase
(TH) loss and delay motor impairment in Parkinson's disease remain unidentified. The rat …

Background: Alleviation of motor impairment by aerobic exercise (AE) in Parkinsons disease
(PD) points to a CNS response that could be targeted by therapeutic approaches, but …