Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised
as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …

Alternative polyadenylation (APA) is a pervasive mechanism in the regulation of most
human genes, and its implication in diseases including cancer is only beginning to be …

Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in
intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA) …

Cancer cells re-program their metabolic machinery to meet the requirements of malignant
transformation and progression. Glutaminase 1 (GLS1) was traditionally known as a …

Background Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor
prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver …

Growth-promoting signaling molecules, including the mammalian target of rapamycin
complex 1 (mTORC1), drive the metabolic reprogramming of cancer cells required to …

Glutamine is an essential nutrient for cancer cell proliferation, especially in the context of
citric acid cycle anaplerosis. In this manuscript we present results that collectively …

The release of GA (mitochondrial glutaminase) from neurons following acute ischaemia or
during chronic neurodegenerative diseases may contribute to the propagation of glutamate …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …