Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could
support or augment recovery. Targeting these cells requires a clearer understanding of their …

Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …

Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, and there
is no effective clinical treatment, to date. Due to the complex pathological process involved …

Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid
cells have the potential to worsen damage and/or to assist in healing. We define the …

Understanding the regulation of axon growth after injury to the adult central nervous system
(CNS) is crucial to improve neural repair. Following acute focal CNS injury, astrocytes are …

Spinal cord injury (SCI) causes lifelong debilitating conditions. Previous works demonstrated
the essential role of the immune system in recovery after SCI. Here, we explored the …

Ependymal cells, a dormant population of ciliated progenitors found within the central canal
of the spinal cord, undergo significant alterations after spinal cord injury (SCI) …