The existence of subpopulations of cells in cancers with increased tumor-initiating capacities
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …

While the eukaryotic genome is the same throughout all somatic cells in an organism, there
are specific structures and functions that discern one type of cell from another. These …

DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …

A single cytosine–guanine dinucleotide (CpG) site within coagulation factor II (thrombin)
receptor-like 3 (F2RL3) was recently found to be hypomethylated in peripheral blood …

Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …

Background Breast cancer formation is associated with frequent changes in DNA
methylation but the extent of very early alterations in DNA methylation and the biological …

Perturbations in methyl group metabolism and homocysteine balance have emerged over
the past few decades as having defining roles in a number of pathological conditions …

Amyotrophic lateral sclerosis (ALS) is a terminal disease involving the progressive
degeneration of motor neurons within the motor cortex, brainstem and spinal cord. Most …

Epigenetic mechanisms govern the transcription of the genome. Research with model
systems reveals that environmental conditions can directly influence epigenetic mechanisms …

Disturbed epigenetic mechanisms, which developmentally regulate gene expression via
modifications to DNA, histone proteins, and chromatin, have been hypothesized to play a …