Migraine is a common condition with disabling attacks that burdens people in the prime of
their working lives. Despite years of research into migraine pathophysiology and …

Calcitonin gene-related peptide (CGRP), a 37 amino-acid neuropeptide found mostly in
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …

Objective To incorporate recent research findings, expert consensus, and patient
perspectives into updated guidance on the use of new acute and preventive treatments for …

Migraine is a common and disabling neurological disorder, with several manifestations, of
which pain is just one. Despite its worldwide prevalence, there remains a paucity of targeted …

Abstract Calcitonin Gene-Related Peptide (CGRP) plays a pivotal role in migraine
pathophysiology. Two types of CGRP function-blocking modalities, monoclonal antibodies …

Background Individuals using onabotulinumtoxinA as a preventive migraine treatment often
use acute treatments for breakthrough attacks. Data on real-world effectiveness of the small …

Background Photophobia is a potentially debilitating symptom often found in dry eye
disease (DE), migraine and traumatic brain injury (TBI). Methods We conducted a review of …

Aim Development and characterization of a novel injury-free preclinical model of migraine-
like pain allowing mechanistic assessment of both acute and preventive treatments …

The development, maintenance and metastasis of solid tumors are highly dependent on the
formation of blood and lymphatic vessels from pre-existing ones through a series of …

The standard of care paradigm for migraine treatment has been based almost exclusively on
approaches that grew out of the happenstance use of market pharmaceuticals. Only …