Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

Cholesterol is a multifacetted molecule. First, it serves as an essential membrane
component, as a cofactor for signaling molecules and as a precursor for steroid hormones; …

Neurons have a high demand for cholesterol to develop and maintain membrane‐rich
structures like axons, dendrites and synapses, but it remains unclear, whether they can …

Glucose had long been thought to fuel oxidative metabolism in active neurons until the
recently proposed astrocyte-neuron lactate shuttle hypothesis (ANLSH) challenged this …

In this study we have investigated the mechanisms leading to mitochondrial damage in
cultured neurons following sustained exposure to nitric oxide. Thus, the effects upon …

β-Amyloid deposition and compromised energy metabolism both occur in vulnerable brain
regions in Alzheimer's disease. It is not known whether β-amyloid is the cause of impairment …

Lactate is an important metabolic substrate for the brain during the postnatal period and also
plays a crucial role in the traffic of metabolites between astrocytes and neurons. However, to …

Astrocytes are interposed between the pericapillary space and neuronal membranes.
Consequently, they may represent an important intermediary element between the source of …

Cytokine‐stimulated astrocytes produce nitric oxide (NO), which, along with its metabolite
peroxynitrite (ONOO‐), can inhibit components of the mitochondrial respiratory chain. We …

The brain is the most cholesterol-rich organ in mammals. However, cholesterol metabolism
in the brain is completely independent of other tissues due to the presence of the blood …