Insulin-like growth factor-2 (IGF-2) in fibrosis

Y Zhu, L Chen, B Song, Z Cui, G Chen, Z Yu, B Song - Biomolecules, 2022 - mdpi.com
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth
factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three …

[HTML][HTML] Biomarkers Identification in the Microenvironment of Oral Squamous Cell Carcinoma: A Systematic Review of Proteomic Studies

S Pomella, O Melaiu, L Cifaldi, R Bei, M Gargari… - International Journal of …, 2024 - mdpi.com
An important determinant for oral squamous cell carcinoma (OSCC) onset and outcome is
the composition of the tumor microenvironment (TME). Thus, the study of the interactions …

Tracing the dynamics of gene transcripts after organismal death

AE Pozhitkov, R Neme, T Domazet-Lošo… - Open …, 2017 - royalsocietypublishing.org
In life, genetic and epigenetic networks precisely coordinate the expression of genes—but in
death, it is not known if gene expression diminishes gradually or abruptly stops or if specific …

Cathepsins trigger cell death and regulate radioresistance in glioblastoma

X Ding, C Zhang, H Chen, M Ren, X Liu - Cells, 2022 - mdpi.com
Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to
find sensitive and specific molecular targets. In this work, we reveal the relationship between …

[PDF][PDF] RETRACTED: NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR …

H Tang, C Tan, X Cao, Y Liu, H Zhao, Y Liu… - Frontiers in …, 2021 - frontiersin.org
Autophagy pathways play an important role in immunity and inflammation via pathogen
clearance mechanisms mediated by immune cells, such as macrophages and neutrophils …

Fisetin attenuates doxorubicin‐induced cardiotoxicity by inhibiting the insulin‐like growth factor II receptor apoptotic pathway through estrogen receptor‐α/‐β activation

KH Lin, S Ramesh, S Agarwal, WW Kuo… - Phytotherapy …, 2023 - Wiley Online Library
Doxorubicin (DOX), an effective chemotherapeutic drug, has been used to treat various
cancers; however, its cardiotoxic side effects restrict its therapeutic efficacy. Fisetin, a …

miR‐203 accelerates apoptosis and inflammation induced by LPS via targeting NFIL3 in cardiomyocytes

Y Li, X Liu, A Du, X Zhu, B Yu - Journal of cellular biochemistry, 2019 - Wiley Online Library
Myocarditis is an inflammatory disease of the myocardium. MicroRNA‐203 (miR‐203) is
involved in various physiological and pathological processes. In this work, we aimed to …

A Potential Role of NFIL3 in Atherosclerosis

GG Zeng, J Zhou, WL Jiang, J Yu, GY Nie, J Li… - Current problems in …, 2024 - Elsevier
Abstract Nuclear factor interleukin-3 (NFIL3), a proline-and acidic-residue-rich (PAR) bZIP
transcription factor, is called the E4 binding protein 4 (E4BP4) as well, which is relevant to …

Estrogen and/or estrogen receptor α inhibits BNIP3-induced apoptosis and autophagy in H9c2 cardiomyoblast cells

BC Chen, YJ Weng, MA Shibu, CK Han… - International Journal of …, 2018 - mdpi.com
The process of autophagy in heart cells maintains homeostasis during cellular stress such
as hypoxia by removing aggregated proteins and damaged organelles and thereby protects …

Anthocyanin attenuates doxorubicin-induced cardiomyotoxicity via estrogen receptor-α/β and stabilizes HSF1 to inhibit the IGF-IIR apoptotic pathway

PC Huang, WW Kuo, CY Shen, YF Chen… - International journal of …, 2016 - mdpi.com
Doxorubicin (Dox) is extensively used for chemotherapy in different types of cancer, but its
use is limited to because of its cardiotoxicity. Our previous studies found that doxorubicin …