Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …

Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …

Direct implantation of mesenchymal stem cells (MSCs) for cartilage and bone tissue
engineering faces challenges, such as immune rejection and loss of cellular viability or …

In the US, 30% of adults suffer joint pain, most commonly in the knee, which severely limits
mobility and is often attributed to injury of cartilage and underlying bone in the joint. Current …

Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen
(COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic …

Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

Abstract Purpose of Review Articular chondrocytes are exclusively responsible for the
turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are …

Abnormal mechanical loading often leads to the progressive degradation of cartilage and
causes osteoarthritis (OA). Although multiple mechanoresponsive strategies based on …

The cellular and molecular mechanisms responsible for the initiation and progression of
osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely …

The extracellular matrix (ECM) is an intricate network of proteins that surrounds cells and
has a central role in establishing an environment that is conducive to tissue-specific cell …