Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications

PT van Leeuwen, S Brul, J Zhang… - FEMS microbiology …, 2023 - academic.oup.com
The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …

[HTML][HTML] Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes

SL Bishop, M Drikic, S Wacker, YY Chen… - Mucosal …, 2022 - Elsevier
Advances in technology and software have radically expanded the scope of metabolomics
studies and allow us to monitor a broad transect of central carbon metabolism in routine …

Dynamic metabolic interactions and trophic roles of human gut microbes identified using a minimal microbiome exhibiting ecological properties

SA Shetty, I Kostopoulos, SY Geerlings… - The ISME …, 2022 - academic.oup.com
Microbe–microbe interactions in the human gut are influenced by host-derived glycans and
diet. The high complexity of the gut microbiome poses a major challenge for unraveling the …

A bacterial sialidase mediates early-life colonization by a pioneering gut commensal

E Buzun, CY Hsu, K Sejane, RE Oles, AV Ayala… - Cell Host & Microbe, 2024 - cell.com
The early microbial colonization of the gastrointestinal tract can have long-term impacts on
development and health. Keystone species, including Bacteroides spp., are prominent in …

Impact of bacteriocin-producing strains on bacterial community composition in a simplified human intestinal microbiota

NS Ríos Colombo, M Perez-Ibarreche… - Frontiers in …, 2023 - frontiersin.org
Bacteriocins are antimicrobial peptides that have been studied for decades as food bio-
preservatives or as alternatives to antibiotics. They also have potential as modulators of the …

Microbiota-directed biotherapeutics: Considerations for quality and functional assessment

EE Fekete, D Figeys, X Zhang - Gut Microbes, 2023 - Taylor & Francis
Mounting evidence points to causative or correlative roles of gut microbiome in the
development of a myriad of diseases ranging from gastrointestinal diseases, metabolic …

[HTML][HTML] MAIT cell activation is reduced by direct and microbiota-mediated exposure to bisphenols

JL Krause, B Engelmann, UN Da Rocha… - Environment …, 2022 - Elsevier
Oral uptake is the primary route of human bisphenol exposure, resulting in an exposure of
the intestinal microbiota and intestine-associated immune cells. Therefore, we compared the …

Designs and methodologies to recreate in vitro human gut microbiota models

F Biagini, C Daddi, M Calvigioni, C De Maria… - Bio-Design and …, 2023 - Springer
The human gut microbiota is widely considered to be a metabolic organ hidden within our
bodies, playing a crucial role in the host's physiology. Several factors affect its composition …

[HTML][HTML] The glyphosate formulation Roundup® LB plus influences the global metabolome of pig gut microbiota in vitro

JL Krause, SB Haange, SS Schäpe… - Science of the Total …, 2020 - Elsevier
Glyphosate is the world's most widely used herbicide, and its potential side effects on the
intestinal microbiota of various animals, from honeybees to livestock and humans, are …

In vitro and in vivo models for evaluating the oral toxicity of nanomedicines

S Lama, O Merlin-Zhang, C Yang - Nanomaterials, 2020 - mdpi.com
Toxicity studies for conventional oral drug formulations are standardized and well
documented, as required by the guidelines of administrative agencies such as the US Food …