Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Recent outbreaks of Clostridium difficile infection (CDI) in North America have been due to a
more virulent, possibly more resistant strain that causes more-severe disease, making …

BACKGROUND & AIMS: Infection with Clostridium difficile causes nosocomial antibiotic–
associated diarrhea and colitis. Hamsters historically have been used to investigate disease …

The incidence and severity of Clostridium difficile-associated disease (CDAD) is increasing,
and standard treatment is not always effective. Therefore, more-effective antimicrobial …

Models of Clostridium difficile infection (C. difficile) have been used extensively for
Clostridium difficile (C. difficile) research. The hamster model of C. difficile infection has …

The Gram-positive anaerobic bacterium Clostridium difficile produces toxins A and B, which
can cause a spectrum of diseases from pseudomembranous colitis to C. difficile-associated …

Clostridium difficile (C. difficile) is a Gram positive, anaerobic bacterium that infects the
lumen of the large intestine and produces toxins. This results in a range of syndromes from …

Clostridium difficile (C. difficile) is the most common cause of nosocomial antibiotic-
associated diarrhea and the etiologic agent of pseudomembranous colitis. The clinical …

The major virulence factors of Clostridium difficile infection (CDI) are two large exotoxins A
(TcdA) and B (TcdB). However, our understanding of the specific roles of these toxins in CDI …

In the past decade Clostridium difficile has become a bacterial pathogen of global
significance. Epidemic strains have spread throughout hospitals, while community acquired …