The application of artificial intelligence (AI) has been considered a revolutionary change in
drug discovery and development. In 2020, the AlphaFold computer program predicted …

Simple Summary Human primary liver cancers have a poor prognosis. At present, there are
limited treatment alternatives, and to understand the molecular aspects of liver …

A lack of relevant genetic models and cell lines hampers our understanding of
hepatoblastoma pathogenesis and the development of new therapies for this neoplasm …

The most frequent liver tumor in children is hepatoblastoma (HB), which derives from
embryonic parenchymal liver cells or hepatoblasts. Hepatocellular carcinoma (HCC), which …

Background & Aims Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the
predominant pediatric liver cancer, with limited therapeutic options for patients with …

Hepatocellular carcinoma (HCC) is one of the most dominant causes of neoplasm-related
deaths worldwide. In this study, we identify and characterize HCCL5, a novel cytoplasmic …

Pediatric hepatoblastoma is the most common primary liver cancer in infants and children.
Studies of hepatoblastoma that focus exclusively on tumor cells demonstrate sparse somatic …

Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and
adolescents. Despite overall good prognosis, PLCs display heterogeneous response to …

Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-
activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize …

ABSTRACT Type IIA topoisomerase (TOP2A) is upregulated in hepatocellular carcinoma
(HCC) and its expression is positively correlated with poor prognosis. However, the …