DNA methylation: conducting the orchestra from exposure to phenotype?
FAD Leenen, CP Muller, JD Turner - Clinical epigenetics, 2016 - Springer
Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …
is considered to be one of the principal interfaces between the genome and our …
Long-read sequencing–a powerful tool in viral transcriptome research
Long-read sequencing (LRS) has become increasingly popular due to its strengths in de
novo assembly and in resolving complex DNA regions as well as in determining full-length …
novo assembly and in resolving complex DNA regions as well as in determining full-length …
METTL3-mediated m6A modification is required for cerebellar development
N 6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs
and plays important roles in various biological processes. The formation of m6A is catalyzed …
and plays important roles in various biological processes. The formation of m6A is catalyzed …
Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues
Most human genes generate multiple transcript isoforms. The differential expression of these
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …
A pan-cancer transcriptome analysis reveals pervasive regulation through alternative promoters
Most human protein-coding genes are regulated by multiple, distinct promoters, suggesting
that the choice of promoter is as important as its level of transcriptional activity. However …
that the choice of promoter is as important as its level of transcriptional activity. However …
Widespread and extensive lengthening of 3′ UTRs in the mammalian brain
P Miura, S Shenker, C Andreu-Agullo… - Genome …, 2013 - genome.cshlp.org
Remarkable advances in techniques for gene expression profiling have radically changed
our knowledge of the transcriptome. Recently, the mammalian brain was reported to express …
our knowledge of the transcriptome. Recently, the mammalian brain was reported to express …
Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs
Nervous system function relies on complex assemblies of distinct neuronal cell types that
have unique anatomical and functional properties instructed by molecular programs …
have unique anatomical and functional properties instructed by molecular programs …
A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines
The human genome contains more than 200,000 gene isoforms. However, different isoforms
can be highly similar, and with an average length of 1.5 kb remain difficult to study with short …
can be highly similar, and with an average length of 1.5 kb remain difficult to study with short …
[HTML][HTML] Cilia-associated oxysterols activate smoothened
Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but
how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we …
how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we …
Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription
S Carvalho, AC Raposo, FB Martins… - Nucleic acids …, 2013 - academic.oup.com
Histone H3 of nucleosomes positioned on active genes is trimethylated at Lys36
(H3K36me3) by the SETD2 (also termed KMT3A/SET2 or HYPB) methyltransferase …
(H3K36me3) by the SETD2 (also termed KMT3A/SET2 or HYPB) methyltransferase …