Advances in COVID-19 mRNA vaccine development

E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact

M Lipsitch, F Krammer, G Regev-Yochay… - Nature Reviews …, 2022 - nature.com
Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) in fully vaccinated individuals are receiving intense scrutiny because of their importance …

Evaluation of waning of SARS-CoV-2 vaccine–induced immunity: a systematic review and meta-analysis

F Menegale, M Manica, A Zardini, G Guzzetta… - JAMA Network …, 2023 - jamanetwork.com
Importance Estimates of the rate of waning of vaccine effectiveness (VE) against COVID-19
are key to assess population levels of protection and future needs for booster doses to face …

Association between 3 doses of mRNA COVID-19 vaccine and symptomatic infection caused by the SARS-CoV-2 Omicron and Delta variants

EK Accorsi, A Britton, KE Fleming-Dutra, ZR Smith… - Jama, 2022 - jamanetwork.com
Importance Assessing COVID-19 vaccine performance against the rapidly spreading SARS-
CoV-2 Omicron variant is critical to inform public health guidance. Objective To estimate the …

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

S Cele, L Jackson, DS Khoury, K Khan, T Moyo-Gwete… - Nature, 2022 - nature.com
The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B. 1.1. 529),
first identified in Botswana and South Africa, may compromise vaccine effectiveness and …

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

M Hoffmann, N Krüger, S Schulz, A Cossmann… - Cell, 2022 - cell.com
The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become
globally dominant. Further, the high number of mutations in the viral spike protein raised …

Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic

SSA Karim, QA Karim - The lancet, 2021 - thelancet.com
SARS-CoV-2 variant of concern (VoC), omicron, 2 was reported. Omicron emerged in a
COVID-19-weary world in which anger and frustration with the pandemic are rife amid …

[HTML][HTML] Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV …

APS Munro, L Janani, V Cornelius, PK Aley… - The Lancet, 2021 - thelancet.com
Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection …

Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA. 1 and BA. 2 subvariants in Qatar

H Chemaitelly, HH Ayoub, S AlMukdad, P Coyle… - Nature …, 2022 - nature.com
Abstract SARS-CoV-2 Omicron BA. 1 and BA. 2 subvariants are genetically divergent. We
conducted a matched, test-negative, case-control study to estimate duration of protection of …

Effect of mRNA vaccine boosters against SARS-CoV-2 Omicron infection in Qatar

LJ Abu-Raddad, H Chemaitelly… - … England Journal of …, 2022 - Mass Medical Soc
Background Waning of vaccine protection against coronavirus disease 2019 (Covid-19) and
the emergence of the omicron (or B. 1.1. 529) variant of the severe acute respiratory …