On virus growth and form
We review approaches aimed at deciphering the physical mechanisms responsible for viral
structure and assembly. We discuss the basic principles of condensed matter physics …
structure and assembly. We discuss the basic principles of condensed matter physics …
Portal protein: the orchestrator of capsid assembly for the dsDNA tailed bacteriophages and herpesviruses
CL Dedeo, G Cingolani… - Annual review of virology, 2019 - annualreviews.org
Tailed, double-stranded DNA bacteriophages provide a well-characterized model system for
the study of viral assembly, especially for herpesviruses and adenoviruses. A wealth of …
the study of viral assembly, especially for herpesviruses and adenoviruses. A wealth of …
The structure and intermolecular forces of DNA condensates
J Yoo, A Aksimentiev - Nucleic acids research, 2016 - academic.oup.com
Spontaneous assembly of DNA molecules into compact structures is ubiquitous in biological
systems. Experiment has shown that polycations can turn electrostatic self-repulsion of DNA …
systems. Experiment has shown that polycations can turn electrostatic self-repulsion of DNA …
Nonequilibrium dynamics and ultraslow relaxation of confined DNA during viral packaging
ZT Berndsen, N Keller, S Grimes… - Proceedings of the …, 2014 - National Acad Sciences
Many viruses use molecular motors that generate large forces to package DNA to near-
crystalline densities inside preformed viral proheads. Besides being a key step in viral …
crystalline densities inside preformed viral proheads. Besides being a key step in viral …
Cytosine methylation enhances DNA condensation revealed by equilibrium measurements using magnetic tweezers
YJ Yang, HL Dong, XW Qiang, H Fu… - Journal of the …, 2020 - ACS Publications
CpG methylation of DNA is common in mammalian cells. In sperm, the DNA has the highest
level of CpG methylation and is condensed into toroidal structures. How CpG methylation …
level of CpG methylation and is condensed into toroidal structures. How CpG methylation …
Walker-A motif acts to coordinate ATP hydrolysis with motor output in viral DNA packaging
During the assembly of many viruses, a powerful ATP-driven motor translocates DNA into a
preformed procapsid. A Walker-A “P-loop” motif is proposed to coordinate ATP binding and …
preformed procapsid. A Walker-A “P-loop” motif is proposed to coordinate ATP binding and …
Continuity of states between the cholesteric→ line hexatic transition and the condensation transition in DNA solutions
A new method of finely temperature-tuning osmotic pressure allows one to identify the
cholesteric→ line hexatic transition of oriented or unoriented long-fragment DNA bundles in …
cholesteric→ line hexatic transition of oriented or unoriented long-fragment DNA bundles in …
Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor
ATP-powered viral packaging motors are among the most powerful biomotors known. Motor
subunits arranged in a ring repeatedly grip and translocate the DNA to package viral …
subunits arranged in a ring repeatedly grip and translocate the DNA to package viral …
Dynamic measurements of the position, orientation, and DNA content of individual unlabeled bacteriophages
A complete understanding of the cellular pathways involved in viral infections will ultimately
require a diverse arsenal of experimental techniques, including methods for tracking …
require a diverse arsenal of experimental techniques, including methods for tracking …
Single DNA molecule jamming and history-dependent dynamics during motor-driven viral packaging
In many viruses, molecular motors forcibly pack single DNA molecules to near-crystalline
density into∼ 50–100 nm prohead shells,. Unexpectedly, we found that packaging …
density into∼ 50–100 nm prohead shells,. Unexpectedly, we found that packaging …